Panama, a country that bridges the gap between North and South America, offers a delightful mix of urban sophistication and natural beauty. In this itinerary, we’ll take you on a journey through Panama, starting with an exciting one-night stay in Panama City, followed by four nights of eco-adventure in the stunning Bocas del Toro archipelago. Get ready for a whirlwind trip that combines the best of both worlds — the vibrant city life and a serene eco-lodge surrounded by nature.

Day 1: Arrive in Panama City

Your adventure begins as you touch down at Tocumen International Airport in Panama City. Known as the “Crossroads of the World,” Panama City offers a fascinating blend of history, culture, and modernity.

Check in at The American Trade in Casco Viejo

Morning: Explore the Old Town (Casco Viejo)

Start your day by exploring Casco Viejo, the historic district of Panama City. Wander through its cobbled streets lined with colorful colonial buildings, each with a story to tell. Don’t miss landmarks like the Panama Canal Museum and the stunning Metropolitan Cathedral.

Lunch: Savor Panamanian Cuisine

Enjoy a delicious Panamanian lunch at a local restaurant. Be sure to try ceviche, a traditional dish made with fresh seafood, and wash it down with a refreshing glass of chicha, a popular local drink.

Insider’s tip: A cute and light place we enjoy going to breakfast is called Dodó Bon Pan Café. They have fantastic salads, plant-based sandwiches, scrambled tofu breakfasts, pastries, and more…and are right in Casco Viejo.

Afternoon: Visit the Miraflores Locks

Head to the Miraflores Locks Visitor Center to witness the marvel of engineering that is the Panama Canal. The interactive museum provides insight into the canal’s history and its significance to global trade.

Evening: Sunset at Ancon Hill

For a breathtaking panoramic view of the city and the Pacific Ocean, hike up Ancon Hill in the late afternoon. Arriving just before sunset lets you witness the city’s skyline bathed in golden hues.

Night: Dinner and Drinks in Casco Viejo

End your day with dinner at one of Casco Viejo’s trendy restaurants. The area comes alive at night, offering a vibrant nightlife scene. Sip on cocktails and enjoy the city’s lively atmosphere before retiring to your hotel.

Insider’s Tip: For dinner, Casa Catedral is an awesome choice. If you want a dinner-plus experience in one, you could also try Salvaje. They have a Carnival Show during dinner…  And for a fine dining experience, Maito would be a great option, serving Panamanian fare with a twist.

Days 2-5: Eco Paradise in Bocas del Toro

After an eventful day in Panama City, it’s time to embark on a nature-filled journey to Bocas del Toro, a pristine archipelago located in the Caribbean Sea.

Travel to Bocas del Toro

Catch a domestic flight from Panama City to Bocas del Toro’s Isla Colón. Upon arrival, transfer to your chosen eco-lodge.

Welcome to Bocas

From the Albrook Airport, fly out with Air Panama on a quick 50-minute flight to Bocas del Toro where you’ll be picked up for a 35-minute speedboat ride to the lodge.

Settle in at Casa Cayuco Eco-Adventure Lodge

• 5:00pm – Enjoy a dock-side snack (daily).
• Mingle with guests at the bar for a beverage before dinner.
• 7:30pm – enjoy a 3-course dinner plus dessert (daily).

Bocas Day 2

• 7:00am – Enjoy locally grown and specially roasted coffee (daily).
• 8:30am – Enjoy breakfast which is served daily.
• 10am – Mangroves snorkeling guided adventure.
• 12:30pm – Enjoy a delicious chef’s choice lunch (daily).
• 3:30pm – Depart to view turtle hatching. 
• ***Demonstration of a local food product during snack time

Bocas Day 3

• 10am – Zapatillas Island Snorkeling + Beach Adventure
• 2:00pm – Guided Hiking of the Casa Cayuco Sendero
• 4:00pm – Enjoy a massage from our local masseuse.
• 5:00pm – Local Dance Troupe performance visit during snack time

Bocas Day 4

• 10am – Bat Cave, Chocolate Farm, or relax on the property!
• 2:00pm – Salt Creek Village Tour
• 5:00pm – Bread-making class with head baker, Martina and head chef Crucita.

Spend your days in Bocas del Toro exploring its natural wonders. Here are some activities to consider:

• Snorkeling: Discover vibrant coral reefs and marine life in the crystal-clear waters of the archipelago.
• Island Hopping: Visit the neighboring islands, each with its unique charm. Don’t miss Isla Zapatilla for its pristine beaches and Isla Bastimentos for a chance to see the famous red poison dart frog.
• Jungle Trekking: Explore the lush rainforests and take guided hikes to spot wildlife like sloths, monkeys, and exotic birds.
• Kayaking and Paddleboarding: Navigate the calm waters of Bocas del Toro by kayak or paddleboard, giving you a unique perspective of the archipelago.

Panama City’s historical charm and Bocas del Toro’s natural beauty make for a diverse and unforgettable travel experience. In just six days, you’ll have explored the urban delights of the capital and immersed yourself in the serene eco-lodges of the Caribbean archipelago. This trip showcases the best of Panama’s diverse landscapes and cultures, leaving you with memories to cherish for a lifetime. Whether you’re a history buff, nature lover, or adventure seeker, Panama has something for everyone.